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This book presents a completely novel approach to the understanding of ageing, which many believe is an unsolved problem in biology. It explains why ageing exists in animals, and reviews our understanding of it at the biological level. This includes a discussion of the origins and evolution of ageing. The book is not a review of research on ageing, but instead draws on material from a wide range of disciplines, including the very extensive biomedical information about age-related diseases in humans. Understanding Ageing argues that much research needs to be done on the cellular and molecular aspects of ageing, if the origins of these diseases are to be understood, and their prevention made possible. This thought-provoking book will appeal to all students and researchers who are interested in ageing, whether they are working in the clinical or basic research sphere.
This book presents a completely novel approach to the understanding of ageing, which many believe is an unsolved problem in biology. It explains why ageing exists in animals, and reviews our understanding of it at the biological level. This includes a discussion of the origins and evolution of ageing. The book is not a review of research on ageing, but instead draws on material from a wide range of disciplines, including the very extensive biomedical information about age-related diseases in humans. Understanding Ageing argues that much research needs to be done on the cellular and molecular aspects of ageing, if the origins of these diseases are to be understood, and their prevention made possible. This thought-provoking book will appeal to all students and researchers who are interested in ageing, whether they are working in the clinical or basic research sphere.
Preface; Author's note; Acknowledgements; 1. Introduction; 2. The evolved anatomical and physiological design of mammals; 3. Maintenance of the adult organism; 4. Theories of ageing; 5. Cellular ageing; 6. Genetic programmes for ageing; 7. The evolution of longevity; 8. Human disease and ageing; 9. A better understanding of ageing; Notes; References; Author index; Subject index.
This book explains why ageing exists, reviews our understanding of it at the biological level and discusses age-related diseases.
'Robin Holliday offers a superb overview with emphasis on the cellular and molecular biology of ageing ...' Nature 'Holliday writes in a direct and energetic style that makes his text highly readable. I would certainly recommend it to students ... an excellent text.' Linda Partridge, Elsevier Trends in Ecology and Evolution
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