This book provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is of paramount importance for successful synthesis. Numerous techniques relevant to drugs and vaccines are explored, such as conjugation and condensation methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
1. Solution Phase Peptide Synthesis: The Case of Biphalin
Dagmara Tymecka and Aleksandra Misicka
2. Application of Fmoc-SPPS, Thiol-Maleimide Conjugation and Copper(I)-Catalyzed Alkyne-Azide Cycloaddition "Click" Reaction in the Synthesis of a Complex Peptide-Based Vaccine Candidate against Group A Streptococcus
Chuankai Dai, Rachel J. Stephenson, Mariusz Skwarczynski, and Istvan Toth
Ramkrishna Adhikary and Philip E. Dawson
4. Anhydrous Hydrogen Fluoride Cleavage in Boc Solid Phase Peptide Synthesis
Kirtikumar B. Jadhav, Katrina J. Woolcock, and Markus Muttenthaler
5. Automated Solid-Phase Peptide Synthesis
Dirk F.H. Winkler
6. New Developments in Microwave-Assisted Solid Phase Peptide Synthesis
Sandeep K. Singh and Jonathan M. Collins
7. Protecting Groups in Peptide Synthesis
Maddeboina Krishnaiah and Martin Conda-Sheridan
8. Synthesis of O-Acyl Isopeptides: Stepwise and Convergent Solid-Phase Synthesis
Taku Yoshiya
9. An Isodipeptide Building Block for Microwave-Assisted Solid-Phase Synthesis of Difficult Sequence-Containing Peptides
10. SPOT Synthesis: The Solid-Phase Peptide Synthesis on Planar Surfaces
Dirk F.H. Winkler
11. Solid-Phase Synthesis of Wollamide Cyclohexapeptide Analogs
Allan M. Prior and Dianqing Sun
12. Synthesis of Branched Peptides via a Side-Chain Benzyl Ester
Junjie Liu, Jian Li, Xiaobo Tian, Feng Tang, and Wei Huang
13. Solid Phase Synthesis of Octapeptin Lipopeptides
Karl A. Hansford, Zyta M. Ziora, Matthew A. Cooper, and Mark A.T. Blaskovich
14. Peptidomimetic Synthesis¿Drug Discovery for Alzheimer's Disease
Yoshio Hamada and Zyta M. Ziora
15. Synthesis of Amide Backbone-Modified Peptides
Abu-Baker M. Abdel-Aal, Richard Raz, George Papageorgiou, and John Offer
16. Synthesis of NickFects, a New Family of CPPs, by Solid-Phase Peptide Synthesis
Piret Arukuusk and Ülo Langel
17. Chemoenzymatic Synthesis of HIV-1 Glycopeptide Antigens
Guanghui Zong, Chao Li, and Lai-Xi Wang
18. Synthesis of Antimicrobial Lipopeptides Using the "CLipPA" Thiol-Ene Reaction
Yann O. Hermant, Alan J. Cameron, Paul W.R. Harris, and Margaret A. Brimble
19. Decarboxylative Couplings for Late-Stage Peptide Modifications
Meng Yao Zhang and Lara R. Malins
20. Peptide and Pseudopeptide Bond Synthesis in Phosphorus Dipeptide Analogs
Artur Mucha and Pawel Kafarski
21. Micro-Bioreactor Techniques for the Production and Spectroscopic Characterization of Microbial Peptides
Zeinab G. Khalil, Angela A. Salim, and Robert J. Capon
22. Metal Peptide Complexes for Study Neurodegenerative Diseases
Mariusz Mital, Jakub P. Sek, and Zyta M. Ziora
Show moreThis book provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is of paramount importance for successful synthesis. Numerous techniques relevant to drugs and vaccines are explored, such as conjugation and condensation methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
1. Solution Phase Peptide Synthesis: The Case of Biphalin
Dagmara Tymecka and Aleksandra Misicka
2. Application of Fmoc-SPPS, Thiol-Maleimide Conjugation and Copper(I)-Catalyzed Alkyne-Azide Cycloaddition "Click" Reaction in the Synthesis of a Complex Peptide-Based Vaccine Candidate against Group A Streptococcus
Chuankai Dai, Rachel J. Stephenson, Mariusz Skwarczynski, and Istvan Toth
Ramkrishna Adhikary and Philip E. Dawson
4. Anhydrous Hydrogen Fluoride Cleavage in Boc Solid Phase Peptide Synthesis
Kirtikumar B. Jadhav, Katrina J. Woolcock, and Markus Muttenthaler
5. Automated Solid-Phase Peptide Synthesis
Dirk F.H. Winkler
6. New Developments in Microwave-Assisted Solid Phase Peptide Synthesis
Sandeep K. Singh and Jonathan M. Collins
7. Protecting Groups in Peptide Synthesis
Maddeboina Krishnaiah and Martin Conda-Sheridan
8. Synthesis of O-Acyl Isopeptides: Stepwise and Convergent Solid-Phase Synthesis
Taku Yoshiya
9. An Isodipeptide Building Block for Microwave-Assisted Solid-Phase Synthesis of Difficult Sequence-Containing Peptides
10. SPOT Synthesis: The Solid-Phase Peptide Synthesis on Planar Surfaces
Dirk F.H. Winkler
11. Solid-Phase Synthesis of Wollamide Cyclohexapeptide Analogs
Allan M. Prior and Dianqing Sun
12. Synthesis of Branched Peptides via a Side-Chain Benzyl Ester
Junjie Liu, Jian Li, Xiaobo Tian, Feng Tang, and Wei Huang
13. Solid Phase Synthesis of Octapeptin Lipopeptides
Karl A. Hansford, Zyta M. Ziora, Matthew A. Cooper, and Mark A.T. Blaskovich
14. Peptidomimetic Synthesis¿Drug Discovery for Alzheimer's Disease
Yoshio Hamada and Zyta M. Ziora
15. Synthesis of Amide Backbone-Modified Peptides
Abu-Baker M. Abdel-Aal, Richard Raz, George Papageorgiou, and John Offer
16. Synthesis of NickFects, a New Family of CPPs, by Solid-Phase Peptide Synthesis
Piret Arukuusk and Ülo Langel
17. Chemoenzymatic Synthesis of HIV-1 Glycopeptide Antigens
Guanghui Zong, Chao Li, and Lai-Xi Wang
18. Synthesis of Antimicrobial Lipopeptides Using the "CLipPA" Thiol-Ene Reaction
Yann O. Hermant, Alan J. Cameron, Paul W.R. Harris, and Margaret A. Brimble
19. Decarboxylative Couplings for Late-Stage Peptide Modifications
Meng Yao Zhang and Lara R. Malins
20. Peptide and Pseudopeptide Bond Synthesis in Phosphorus Dipeptide Analogs
Artur Mucha and Pawel Kafarski
21. Micro-Bioreactor Techniques for the Production and Spectroscopic Characterization of Microbial Peptides
Zeinab G. Khalil, Angela A. Salim, and Robert J. Capon
22. Metal Peptide Complexes for Study Neurodegenerative Diseases
Mariusz Mital, Jakub P. Sek, and Zyta M. Ziora
Show moreSolution Phase Peptide Synthesis: The Case of Biphalin.- Application of Fmoc-SPPS, Thiol-Maleimide Conjugation and Copper(I)-Catalyzed Alkyne-Azide Cycloaddition “Click” Reaction in the Synthesis of a Complex Peptide-Based Vaccine Candidate against Group A Streptococcus.- In Situ Neutralization Protocols for Boc-SPPS.- Anhydrous Hydrogen Fluoride Cleavage in Boc Solid Phase Peptide Synthesis.- Automated Solid-Phase Peptide Synthesis.- New Developments in Microwave-Assisted Solid Phase Peptide Synthesis.- Protecting Groups in Peptide Synthesis.- Synthesis of O-Acyl Isopeptides: Stepwise and Convergent Solid-Phase Synthesis.- An Isodipeptide Building Block for Microwave-Assisted Solid-Phase Synthesis of Difficult Sequence-Containing Peptides.- SPOT Synthesis: The Solid-Phase Peptide Synthesis on Planar Surfaces.- Solid-Phase Synthesis of Wollamide Cyclohexapeptide Analogs.- Synthesis of Branched Peptides via a Side-Chain Benzyl Ester.- Solid Phase Synthesis of Octapeptin Lipopeptides.- Peptidomimetic Synthesis―Drug Discovery for Alzheimer’s Disease.- Synthesis of Amide Backbone-Modified Peptides.- Synthesis of NickFects, a New Family of CPPs, by Solid-Phase Peptide Synthesis.- Chemoenzymatic Synthesis of HIV-1 Glycopeptide Antigens.- Synthesis of Antimicrobial Lipopeptides Using the “CLipPA” Thiol-Ene Reaction.- Decarboxylative Couplings for Late-Stage Peptide Modifications.- Peptide and Pseudopeptide Bond Synthesis in Phosphorus Dipeptide Analogs.- Micro-Bioreactor Techniques for the Production and Spectroscopic Characterization of Microbial Peptides.- Metal Peptide Complexes for Study Neurodegenerative Diseases.
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