This book builds on the success of previous editions, once again providing hepatologists the most current clinical guide on how to best treat the liver transplant recipient. With an international mix of experienced contributors, this new edition highlights initial indication and selection of the potential recipient, management of the donor organ, post-operative complications in the patient through to acute recovery, long-term follow-up, and continued health. This provides the user a complete guide to the correct clinical management of both the recipient and the donor organ through all stages of transplantation.

Pierre-Alain Clavien, MD, PhD, FACS, FRCS (Eng), FRCS (Ed), Professor and Chairman, Department of Surgery. Head, Division of Visceral & Transplantation Surgery, University Hospital Zurich, Switzerland Professor Clavien is a world-wide renowned surgeon-scientist, currently professor and chairman of the Department of Surgery in Zurich, Switzerland. His areas of research include organ preservation, liver ischemia-reperfusion injury and regeneration, and pathogenesis of cancer, as well as outcome research. He received many competitive grants and awards, including one of the most prestigious prices for scientific research, the Otto Naegeli Award. Dr James Trotter is the Medical Director of Liver Transplantation at Baylor University Medical Center at Dallas. Dr. Trotter's primary interests include end-stage liver disease and the management of liver transplant candidates and recipients. Dr. Trotter specializes in hepatitis C, ascites, complications of portal hypertension, including esophageal varices and hepatic encephalopathy. He also has vast experience in the management of medical complications after liver transplantation including immunosuppression in liver transplant recipients and the treatment of hepatitis C before and after liver transplantation.

Contributors, ix Preface, xv Part 1 Management of the potential transplant recipient 1 Selection and evaluation of the recipient (including retransplantation), 3 Audrey Coilly and Didier Samuel 2 Monitoring the patient awaiting liver transplantation, 13 Andreas Geier and Beat Müllhaupt 3 Management of portal hypertension, 26 Juan Carlos Garcia-Pagan, Juan G. Abraldes and Jaime Bosch 4 Management of renal disease in the liver transplant candidate, 39 Andrés Cárdenas and Pere Ginès 5 Management of hepatopulmonary syndrome and portopulmonary hypertension, 51 Victor I. Machicao and Michael B. Fallon 6 Psychiatric and substance abuse evaluation of the potential liver transplant recipient, 62 Thomas P. Beresford 7 Organ allocation in liver transplantation: ethics, organ supply, and evidencebased practice, 75 Nicole Siparsky, David Axelrod and Richard B. Freeman 8 Viral hepatitis and transplantation, 88 Geoffrey W. McCaughan 9 Metabolic liver diseases, 97 Maureen M.J. Guichelaar and Michael R. Charlton 10 Cholestatic and autoimmune liver disease, 110 Ulrich Beuers 11 Hepatocellular carcinoma, 121 Maria Reig, Alejandro Forner and Jordi Bruix 12 Cholangiocarcinoma, 133 Howard C. Masuoka, Gregory J. Gores and Charles B. Rosen 13 Rare indications for liver transplantation, 145 Stevan A. Gonzalez 14 Liver transplantation in HIV patients, 155 Marion G. Peters and Peter G. Stock 15 Living-donor liver transplantation, 162 Robert S. Brown Jr 16 Fulminant hepatic failure, 176 Michael A. Heneghan and William Bernal Part 2 Donor issues and management in the perioperative period 17 Extended-criteria donor, 191 Ashraf Mohammad El-Badry and Mickael Lesurtel 18 Liver transplantation using donors after cardiac death, 201 Paolo Muiesan, Laura Tariciotti and Chiara Rocha 19 Transmission of malignancies and infection through donor organs, 216 Aaron M. Winnick and Lewis Teperman 20 The transplant operation, 229 Philipp Dutkowski, Olivier de Rougemont and Pierre-Alain Clavien 21 Difficult surgical patients, 238 Philipp Dutkowski, Stefan Breitenstein and Pierre-Alain Clavien 22 Domino and split-liver transplantation, 246 Abhideep Chaudhary and Abhinav Humar 23 Surgical aspects of living-donor transplantation, 255 Kelvin K.C. Ng and Sheung Tat Fan 24 Anesthesia, 266 Beatrice Beck-Schimmer 25 Coagulation and blood transfusion management, 276 Herman G.D. Hendriks, Ton Lisman and Robert J. Porte 26 Critical care of the liver transplant recipient, 286 Markus Béchir, Erik Schadde and Philipp Dutkowski 27 Rejection and immunosuppression trends in liver transplantation, 297 James F. Trotter 28 Vascular complications after liver transplantation, 311 Goran Klintmalm and Srinath Chinnakotla 29 Biliary complications following liver transplantation, 319 Sanna op den Dries, Robert C. Verdonk and Robert J. Porte 30 Role of histopathology, 332 Achim Weber Part 3 Chronic problems in the transplant recipient 31 Medical problems after liver transplantation, 347 Eberhard L. Renner and Marco Puglia 32 Prevention and treatment of recurrent HBV and HCV infection, 361 Ed Gane 33 Recurrence of the original disease, 372 James Neuberger 34 Infections in the liver transplant recipient, 380 Nicolas J. Mueller and Jay A. Fishman 35 Cutaneous diseases in liver transplant recipients, 389 Sylvie Euvrard and Jean Kanitakis 36 Post-transplant lymphoproliferative disorder and other malignancies after liver transplantation, 398 Natasha Chandok and Kymberly D.S. Watt 37 Sexual function and fertility after liver transplantation, 406 Andreas Geier and Beat Müllhaupt Part 4 Pediatric liver transplantation 38 Special considerations in pediatric liver transplantation, 419 Brandy Ries Lu and Ronald J. Sokol Multiple choice questions, 431 Answers, 446 Index, 451