Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole.  Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge.  In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors.  Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem.  An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions. 

1 Introduction to endocrine disruptors and Puberty   Evanthia Diamanti-Kandarakis   Andrea C. Gore

Part I: EDCs, endocrine systems, and puberty   2 In utero exposure to environmental chemicals - Lessons from maternal cigarette smoking and its effects on gonad development and puberty    Rebecca McKinlay   Peter O'Shaughnessey   Richard M. Sharpe   Paul A. Fowler

3 Reproductive Neuroendocrine Targets of Developmental Exposure to Endocrine Disruptors    Sarah M. Dickerson   Stephanie L. Cunningham   Andrea C. Gore

4 Endocrine disruptors and puberty disorders from mice to men (and women)    Alberto Mantovani

5 Thyroid hormone regulation of mammalian reproductive development and the potential impact of endocrine disrupting chemicals   Kara Renee Thoemke   Thomas William Bastian   Grant Wesley Anderson

Part II: Developmental exposure to endocrine disruptors and adverse reproductive outcomes   6 Developmental exposure to endocrine disruptors and ovarian function    Evanthia Diamanti-Kandarakis   Eleni Palioura   Eleni A.Kandaraki

7 Developmental exposure to environmental endocrine disruptors and adverse effects on mammary gland development      Suzanne Fenton   Lydia M. Beck   Aditi R. Borde   Jennifer Rayner

8 Developmental exposure to endocrine disruptors and male urogenital tract malformations    Mariana F. Fernandez   Nicolas Olea, MD PhD

9 EDC exposures and the development of reproductive and non-reproductive behaviors    Amy B. Wisniewski   Craige C. Wrenn   Ashwini Mallappa

Part III. Developmental exposure to endocrine disruptors and metabolic disorders   10 Adipocytes as target cells for endocrine disruption    Amanda Janesick   Bruce Blumberg

11 Altered Glucose Homeostasis Resulting From Developmental Exposures To Endocrine Disruptors   Alan Schneyer   Melissa Brown

12 Developmental Exposure to Endocrine Disrupting Chemicals: Is there a Connection with Birth and Childhood Weights?     Elizabeth E. Hatch   Jessica W Nelson   Rebecca Triosi   Linda Titus

Part IV. EDCs and Human Health   13 The Impact Of Endocrine Disruptors On Female Pubertal Timing   Jean-Pierre Bourguignon   Anne-Simone Parent

14 The influence of endocrine disruptors on Male Pubertal Timing    Xiu-feng Wu   Ningning Zhang Mary M. Lee

15 Secular Trends in Pubertal Timing: A Role for Environmental Chemical Exposure?   Vincent F. Garry   Peter Truran, PhD