Of the 121,000 people on donor lists in the U.S., over 100,000 need kidney transplants and thousands die each year while waiting. Bioprinting aspires to build healthy kidney tissue from a patient's own cells and transplant this to boost failing kidneys without fear of rejection... As the 21st century dawned, a handful of inspired scientists tried to use 3D printing to create living human tissue. Their vision was to restore the
health of people with intractable injuries, such as worn out cartilage, severed nerves, ailing kidneys, failing heartsDLthe gamut of human frailties. Their modest success energized others to join the quest. Now, after
two decades of ingenious effort and hard work, they have carved out a vibrant new discipline: bioprinting. In Bioprinting: To Make Ourselves Anew, physicist Kenneth Douglas casts an eye over the achievements and future of bioprinting. He explains the science with rigor but with a minimum of technical baggage. This is the first book on the subject written expressly for the lay audience: accessible and even entertaining. Douglas interviewed two dozen bioprinting
researchers from around the world, and he enriches the narrative by sharing stories from the scientists behind the science. These contemporary vignettes are complemented by historical accounts of the women and
men whose prescient contributions were foundational to the development of bioprinting. The book describes the challenges and accomplishments in the bioprinting of blood vessels, cartilage, skin, bone, skeletal muscle, neuromuscular junctions, liver, heart, lung, kidney, and so-called organs-on-a-chip, as well as the challenges of providing a blood supply and nerves to bioprinted tissues. This is a compelling tale of a work in progress: to imitate nature and help heal
people with debilitating afflictions.
Of the 121,000 people on donor lists in the U.S., over 100,000 need kidney transplants and thousands die each year while waiting. Bioprinting aspires to build healthy kidney tissue from a patient's own cells and transplant this to boost failing kidneys without fear of rejection... As the 21st century dawned, a handful of inspired scientists tried to use 3D printing to create living human tissue. Their vision was to restore the
health of people with intractable injuries, such as worn out cartilage, severed nerves, ailing kidneys, failing heartsDLthe gamut of human frailties. Their modest success energized others to join the quest. Now, after
two decades of ingenious effort and hard work, they have carved out a vibrant new discipline: bioprinting. In Bioprinting: To Make Ourselves Anew, physicist Kenneth Douglas casts an eye over the achievements and future of bioprinting. He explains the science with rigor but with a minimum of technical baggage. This is the first book on the subject written expressly for the lay audience: accessible and even entertaining. Douglas interviewed two dozen bioprinting
researchers from around the world, and he enriches the narrative by sharing stories from the scientists behind the science. These contemporary vignettes are complemented by historical accounts of the women and
men whose prescient contributions were foundational to the development of bioprinting. The book describes the challenges and accomplishments in the bioprinting of blood vessels, cartilage, skin, bone, skeletal muscle, neuromuscular junctions, liver, heart, lung, kidney, and so-called organs-on-a-chip, as well as the challenges of providing a blood supply and nerves to bioprinted tissues. This is a compelling tale of a work in progress: to imitate nature and help heal
people with debilitating afflictions.
Foreword, by Donald E. Ingber
Preface
Acknowledgments
Introduction: Frailty, Thy Name is Human
Chapter 1: Printing Paradigms
Chapter 2: All About Cells
Chapter 3: Bioprinted CartilageDLThe Dream and the Devilish
Details
Chapter 4: VascularizationDLGetting Blood from Here to There,
Everywhere
Chapter 5: InnervationDLThe Body's Internet
Chapter 6: Skin and BonesDLand Muscle Too
Chapter 7: The LiverDLRegenerative Tissue That Can Almost Bioprint
Itself
Chapter 8: The HeartDLCardiac Patches, Calcium, and Contraction
Forces
Chapter 9: Organs-on-a-ChipDLTissues for Testing
Chapter 10: The KidneyDLThe Ne Plus Ultra of Filters
Chapter 11: What's in the Offing?
Epilogue
Glossary
Index
Kenneth Douglas is a research faculty member in the Department of
Physics at the University of Colorado Boulder. He earned a BA in
mathematics and an MS in physics at the University of Chicago and a
PhD in physics at the University of Colorado Boulder. Douglas'
laboratory created the strategy of employing the surface layers of
bacterial extremophiles as biomolecular masks to generate ordered
nanostructured materials. His first book was DNA
Nanoscience: From Prebiotic Origins to Emerging Nanotechnology
(2017).
This book is superb! Ken Douglas has an amazing talent for weaving
in and out of complicated topics and making them easy to
understand. He writes in an engaging, conversational style, taking
the reader inside the laboratory and introducing the personalities
behind the science. Using down-to-earth examples and descriptive
language, he makes complex scientific concepts come to life for the
general public. He has done a magnificent job outlining what has
been accomplished to date and the challenges that remain. Well
done, Ken Douglas!
*Anthony Atala, MD, G. Link Professor and Director, Wake Forest
Institute for Regenerative Medicine*
The amount and breadth of basic research in bioprinting is
astounding. It is a huge mix of approaches with cell biology,
tissue engineering, and printing methods that start from scratch
with basic cells and create living tissues. Douglas takes us
through this maze step by step and makes historical and clinical
sense of the direction and pace of this research.
*Charles "Chuck" W. Hull, Inventor of Stereolithography (a.k.a. 3D
Printing); Co-Founder, Executive Vice President, and Chief
Technical Officer, 3D Systems*
In this book, Ken Douglas tells how bioprinting first emerged at
the turn of the 21st century, the enormous potential it offers for
transforming the field of organ transplantation, and the real
challenges that must be overcome in order for it to succeed and
have an impact on the future of health care. It is a story of
creativity, drive, perseverance, and passion, and it is told by
recounting the personal stories of many of the key scientists who
have led the chase.
*From the Foreword by Donald E. Ingber, MD, Director, Wyss
Institute for Biologically Inspired Engineering, Harvard
University*
Magic happens when we combine a 3D printer with tissue engineering
and regenerative medicine. Add materials science, biotechnology,
and medical technology, and the result is an explosion of
innovation in 3D engineered tissues. Through a storytelling method,
this fine book provides readers with insights into how bioprinting
has changed tissue engineering and regenerative medicine and how it
can change the way we approach human diseases in the future.
*Dong-Woo Cho, Nam-Go Chair Professor, Department of Mechanical
Engineering, Pohang University of Science and Technology (POSTECH),
South Korea; Director, Center for Rapid Prototyping-Based 3D
Tissue/Organ Printing*
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