The Vein Book provides complete, authoritative, and up-to-date information about venous function and dysfunction, bridging the gap between clinical medicine and basic science. It is the single most authoritative resource on veins and venous circulation.
John J. Bergan, MD, FACS, FACPh, FRCS, pioneered a new era of diagnosis and treatment for venous conditions, expanding the scope of research and discovering new frontiers in phlebology. As a clinical vascular surgeon, physician, scientist, and respected teacher of vascular surgery, he has published over 800 academic papers and authored or edited more than 40 textbooks. He has served as president for all the major vascular surgery societies and resided on editorial boards of all major surgical and vascular journals, including the Journal of Vascular Surgery, Annals of Vascular Surgery, and the British Journal of Surgery. Additionally, he was a co-founder of the American Venous Forum and American College of Phlebology. Nisha Bunke, MD, FACPh, is the Director of La Jolla Vein Care, Volunteer Clinical Instructor of Surgery at the University of California San Diego School of Medicine, member of the Scripps Ximed Medical Group.
Part I: Basic Considerations; 1. Historical Introduction; Alberto Caggiati and Claudio Allegra; 2. Venous Embryology and Anatomy; Geza Mozes and Peter Gloviczki; 3. Epidemiology of Chronic Peripheral Venous Disease; Michael H. Criqui, Julie O. Denenberg, Robert D. Langer, Robert M. Kaplan, and Arnost Fronek; 4. Venous Anatomy, Physiology, and Pathophysiology; John J. Bergan and Luigi Pascarella; 5. Physiologic Testing in Venous Disorders; Jeffrey K. Raines and Jose I. Almeida; 6. Inappropriate Leukocyte Activation in Venous Disease; Philip Coleridge Smith; 7. Molecular Basis of Venous Insufficiency; 8. Chronic Venous Insufficiency: Molecular Abnormalities and Ulcer Formation; Joseph D. Raffetto; 9. Pathophysiology of Chronic Venous Insufficiency; Peter J. Pappas, Brajesh K. Lal, Frank T. Padberg Jr., Robert W. Zickler, and Walter N. Duran; 10. Mechanism and Effects of Compression Therapy; Hugo Partsch; 11. Classifying Venous Disease; Bo Elkof; Part II: Primary Superficial Venous Insufficiency; 12. Risk Factors, Manifestations, and Clinic Examination of the Patient with Primary Venous Insufficiency; John J. Bergan; 13. Sclerosing Agents; A. Cavezzi and M. Izzo; 14. Sclerotherapy Treatment of Telangiectasias; Robert A. Weiss and Margaret A. Weiss; 15. Complications and Adverse Sequelae of Sclerotherapy; Mitchel P. Goldman; 16. Laser Treatment of Telangiectasias and Reticular Veins; Neil Sadick and Lian Sorhaindo; 17. Overview: Treatment of Venous Insufficiency; John J. Bergan; 18. Ultrasound Examination of the Patient with Primary Venous Insufficiency; Luigi Pascarella and Lisa Mekenas; 19. Sclerotherapy and Ultrasound Sclerotherapy; Paul K. Thibault; 20. Sclerofoam for Treatment of Varicose Veins; Jeanjerome Guex; 21. Sclerosants in Microfoam: A New Approach in Angiology; Juan Cabrera, Maria V. Rubia, and Juan Cabrera Jr.; 22. Ultrasound Guided Catheter and Foam Therapy for Venous Insufficiency; Luigi Pascarella and John J. Bergan; 23. Principles of Treatment of Varicose Veins; Steven E. Zimmet; 24. Inversion Stripping of the Saphenous Vein; John J. Bergan; 25. Neovascularization: An Adverse Response to Proper Groin Dissection; Marianne De Maeseneer; 26. The Changing Importance of the Saphenous Vein: Treating vs. Non-treatment; Paul Pittaluga, Chastanet S, Locret T; 27. Principles of Ambulatory Phlebectomy; Jose I. Almeida and Jeffrey K. Raines; 28. Powered Phlebectomy in Surgery of Varicose Veins; Nick Morrison; 29. Endovenous Radiofrequency and Laser Ablation; Nick Morrison; 30. Treatment of Small Saphenous Vein Reflux; Kenneth Myers, Amy Clough, Stefania Roberts, and Damien Jolley; 31. Recurrent Varicose Veins After Operative Treatment; Michel Perrin; 32. Use of System-Specific Questionnaires and Determination of Quality of Life After Treatment of Varicose Veins; A C Shepherd, M Davis, and A H Davies; 33. Pelvic Congestion Syndrome: Diagnosis and Treatment; G D Richardson; Part III: Venous Thromboembolism; 34. The Epidemiology of Venous Thromboembolism in the Community: Implications for Prevention and Management; John A. Heit; 35. Fundamental Mechanisms in Venous Thrombosis: New Insights; Jose A. Diaz, Daniel D. Myers Jr., and Thomas W. Wakefield; 36. Congenital and Acquired Hypercoagulable Syndromes; Jocelyn A. Segall and Timothy K. Liem; 37. New Ways To Prevent Venous Thromboembolism: Inhibition of Factor Xa and Thrombin; David Bergqvist; 38. Diagnosis of Deep Venous Thrombosis; David A. Frankel and Warner P. Bundens; 39. Thrombotic Risk Assessment: A Hybrid Approach; Joseph A. Caprini; 40. Venous Thromboembolism Prophylaxis in the General Surgical Patient; J.I. Arcelus and Joseph A. Caprini; 41. Conventional Treatment of Deep Venous Thrombosis; Graham F. Pineo and Russell D. Hull; 42. The Diagnosis and Management of Heparin-Induced Thrombocytopenia; Theodore E. Warkentin; 43. Operative Venous Thrombectomy; Anthony J. Comerota and Steven S. Gale; 44. Permanent Vena Cava Filters: Indications, Filter Types, and Results; Ali F. AbuRahma and Patrick A. Stone; 45. Complications of Vena Cava Filters; Teresa L. Carman and Linda M. Graham; 46. Temporary Filters and Prophylactic Indications; John C. McCallum and Nikhil Kansal; 47. Thrombolytic Therapy for Acute Venous Thrombosis; Anthony J. Comerota and Santiago Chahwan; 48. Percutaneous Mechanical Thrombectomy in the Treatment of DVT; Colleen M. Johnson, Pritham P. Reddy, and Robert B. McLafferty; 49. Diagnosis and Management of Primary Axillo-Subclavian Venous Thrombosis; Niren Angle; 50. Subclavian Vein Obstruction: Techniques for Repair and Bypass; Richard J. Sanders; 51. Superficial Thrombophlebitis: Recommendations for Diagnosis and Management; Joann M. Lohr; Part IV: Chronic Venous Insufficiency; 52. The Primary Cause of Chronic Venous Insufficiency; Michel Perrin, Oscar Maleti, and Marzia Lugli; 53. Conventional Surgery for Chronic Venous Insufficiency; William Marston; 54. Subfascial Endoscopic Perforating Vein Surgery (SEPS) for Chronic Venous Insufficiency; Peter Gloviczki, Manju Karla, and Alessandra Puggioni; 55. Ultrasound Guided Sclerotherapy of Perforating Veins In Chronic Insufficiency; Fedor Lurie, Alessandra Puggionu, and Robert L. Kistner; 56. Perforating Veins; John J. Bergan and Luigi Pascarella; 57. Endovenous Treatment of Iliocaval Occlusion; Patricia E. Thorpe and Francisco J. Osse; 58. Popliteal Venous Entrapment; Seshadri Raju; 59. Valvuloplasy In Primary Venous Insufficiency: Development, Performance, and Long-Term Results; Robert L. Kistner, Elna Masuda, and Fedor Lurie; 60. Prosthetic Venous Valves; Michael C. Dalsing; 61. Post-Thrombotic Syndrome: Clinical Features, Pathology, and Treatment; Seshadri Raju; 62. Efficacy of Veno-Active Drugs In Chronic Venous Disease: Survey Of Evidence, Synthesis, And Tentative Recommendations; Michel Perrin and A.A. Ramelet; 63. Medical Management of the Venous Leg Ulcer: Wound Dressings and Adjuvant Agents; Part V: Congenital Venous Abnormalities; 64. Venous Malformations and Tumors: Etiology, Diagnosis, and Management; BB Lee and J Laredo
Show moreThe Vein Book provides complete, authoritative, and up-to-date information about venous function and dysfunction, bridging the gap between clinical medicine and basic science. It is the single most authoritative resource on veins and venous circulation.
John J. Bergan, MD, FACS, FACPh, FRCS, pioneered a new era of diagnosis and treatment for venous conditions, expanding the scope of research and discovering new frontiers in phlebology. As a clinical vascular surgeon, physician, scientist, and respected teacher of vascular surgery, he has published over 800 academic papers and authored or edited more than 40 textbooks. He has served as president for all the major vascular surgery societies and resided on editorial boards of all major surgical and vascular journals, including the Journal of Vascular Surgery, Annals of Vascular Surgery, and the British Journal of Surgery. Additionally, he was a co-founder of the American Venous Forum and American College of Phlebology. Nisha Bunke, MD, FACPh, is the Director of La Jolla Vein Care, Volunteer Clinical Instructor of Surgery at the University of California San Diego School of Medicine, member of the Scripps Ximed Medical Group.
Part I: Basic Considerations; 1. Historical Introduction; Alberto Caggiati and Claudio Allegra; 2. Venous Embryology and Anatomy; Geza Mozes and Peter Gloviczki; 3. Epidemiology of Chronic Peripheral Venous Disease; Michael H. Criqui, Julie O. Denenberg, Robert D. Langer, Robert M. Kaplan, and Arnost Fronek; 4. Venous Anatomy, Physiology, and Pathophysiology; John J. Bergan and Luigi Pascarella; 5. Physiologic Testing in Venous Disorders; Jeffrey K. Raines and Jose I. Almeida; 6. Inappropriate Leukocyte Activation in Venous Disease; Philip Coleridge Smith; 7. Molecular Basis of Venous Insufficiency; 8. Chronic Venous Insufficiency: Molecular Abnormalities and Ulcer Formation; Joseph D. Raffetto; 9. Pathophysiology of Chronic Venous Insufficiency; Peter J. Pappas, Brajesh K. Lal, Frank T. Padberg Jr., Robert W. Zickler, and Walter N. Duran; 10. Mechanism and Effects of Compression Therapy; Hugo Partsch; 11. Classifying Venous Disease; Bo Elkof; Part II: Primary Superficial Venous Insufficiency; 12. Risk Factors, Manifestations, and Clinic Examination of the Patient with Primary Venous Insufficiency; John J. Bergan; 13. Sclerosing Agents; A. Cavezzi and M. Izzo; 14. Sclerotherapy Treatment of Telangiectasias; Robert A. Weiss and Margaret A. Weiss; 15. Complications and Adverse Sequelae of Sclerotherapy; Mitchel P. Goldman; 16. Laser Treatment of Telangiectasias and Reticular Veins; Neil Sadick and Lian Sorhaindo; 17. Overview: Treatment of Venous Insufficiency; John J. Bergan; 18. Ultrasound Examination of the Patient with Primary Venous Insufficiency; Luigi Pascarella and Lisa Mekenas; 19. Sclerotherapy and Ultrasound Sclerotherapy; Paul K. Thibault; 20. Sclerofoam for Treatment of Varicose Veins; Jeanjerome Guex; 21. Sclerosants in Microfoam: A New Approach in Angiology; Juan Cabrera, Maria V. Rubia, and Juan Cabrera Jr.; 22. Ultrasound Guided Catheter and Foam Therapy for Venous Insufficiency; Luigi Pascarella and John J. Bergan; 23. Principles of Treatment of Varicose Veins; Steven E. Zimmet; 24. Inversion Stripping of the Saphenous Vein; John J. Bergan; 25. Neovascularization: An Adverse Response to Proper Groin Dissection; Marianne De Maeseneer; 26. The Changing Importance of the Saphenous Vein: Treating vs. Non-treatment; Paul Pittaluga, Chastanet S, Locret T; 27. Principles of Ambulatory Phlebectomy; Jose I. Almeida and Jeffrey K. Raines; 28. Powered Phlebectomy in Surgery of Varicose Veins; Nick Morrison; 29. Endovenous Radiofrequency and Laser Ablation; Nick Morrison; 30. Treatment of Small Saphenous Vein Reflux; Kenneth Myers, Amy Clough, Stefania Roberts, and Damien Jolley; 31. Recurrent Varicose Veins After Operative Treatment; Michel Perrin; 32. Use of System-Specific Questionnaires and Determination of Quality of Life After Treatment of Varicose Veins; A C Shepherd, M Davis, and A H Davies; 33. Pelvic Congestion Syndrome: Diagnosis and Treatment; G D Richardson; Part III: Venous Thromboembolism; 34. The Epidemiology of Venous Thromboembolism in the Community: Implications for Prevention and Management; John A. Heit; 35. Fundamental Mechanisms in Venous Thrombosis: New Insights; Jose A. Diaz, Daniel D. Myers Jr., and Thomas W. Wakefield; 36. Congenital and Acquired Hypercoagulable Syndromes; Jocelyn A. Segall and Timothy K. Liem; 37. New Ways To Prevent Venous Thromboembolism: Inhibition of Factor Xa and Thrombin; David Bergqvist; 38. Diagnosis of Deep Venous Thrombosis; David A. Frankel and Warner P. Bundens; 39. Thrombotic Risk Assessment: A Hybrid Approach; Joseph A. Caprini; 40. Venous Thromboembolism Prophylaxis in the General Surgical Patient; J.I. Arcelus and Joseph A. Caprini; 41. Conventional Treatment of Deep Venous Thrombosis; Graham F. Pineo and Russell D. Hull; 42. The Diagnosis and Management of Heparin-Induced Thrombocytopenia; Theodore E. Warkentin; 43. Operative Venous Thrombectomy; Anthony J. Comerota and Steven S. Gale; 44. Permanent Vena Cava Filters: Indications, Filter Types, and Results; Ali F. AbuRahma and Patrick A. Stone; 45. Complications of Vena Cava Filters; Teresa L. Carman and Linda M. Graham; 46. Temporary Filters and Prophylactic Indications; John C. McCallum and Nikhil Kansal; 47. Thrombolytic Therapy for Acute Venous Thrombosis; Anthony J. Comerota and Santiago Chahwan; 48. Percutaneous Mechanical Thrombectomy in the Treatment of DVT; Colleen M. Johnson, Pritham P. Reddy, and Robert B. McLafferty; 49. Diagnosis and Management of Primary Axillo-Subclavian Venous Thrombosis; Niren Angle; 50. Subclavian Vein Obstruction: Techniques for Repair and Bypass; Richard J. Sanders; 51. Superficial Thrombophlebitis: Recommendations for Diagnosis and Management; Joann M. Lohr; Part IV: Chronic Venous Insufficiency; 52. The Primary Cause of Chronic Venous Insufficiency; Michel Perrin, Oscar Maleti, and Marzia Lugli; 53. Conventional Surgery for Chronic Venous Insufficiency; William Marston; 54. Subfascial Endoscopic Perforating Vein Surgery (SEPS) for Chronic Venous Insufficiency; Peter Gloviczki, Manju Karla, and Alessandra Puggioni; 55. Ultrasound Guided Sclerotherapy of Perforating Veins In Chronic Insufficiency; Fedor Lurie, Alessandra Puggionu, and Robert L. Kistner; 56. Perforating Veins; John J. Bergan and Luigi Pascarella; 57. Endovenous Treatment of Iliocaval Occlusion; Patricia E. Thorpe and Francisco J. Osse; 58. Popliteal Venous Entrapment; Seshadri Raju; 59. Valvuloplasy In Primary Venous Insufficiency: Development, Performance, and Long-Term Results; Robert L. Kistner, Elna Masuda, and Fedor Lurie; 60. Prosthetic Venous Valves; Michael C. Dalsing; 61. Post-Thrombotic Syndrome: Clinical Features, Pathology, and Treatment; Seshadri Raju; 62. Efficacy of Veno-Active Drugs In Chronic Venous Disease: Survey Of Evidence, Synthesis, And Tentative Recommendations; Michel Perrin and A.A. Ramelet; 63. Medical Management of the Venous Leg Ulcer: Wound Dressings and Adjuvant Agents; Part V: Congenital Venous Abnormalities; 64. Venous Malformations and Tumors: Etiology, Diagnosis, and Management; BB Lee and J Laredo
Show morePart I: Basic Considerations1. Historical IntroductionAlberto Caggiati and Claudio Allegra2. Venous Embryology and AnatomyGeza Mozes and Peter Gloviczki3. Epidemiology of Chronic Peripheral Venous DiseaseMichael H. Criqui, Julie O. Denenberg, Robert D. Langer, Robert M. Kaplan, and Arnost Fronek4. Venous Anatomy, Physiology, and PathophysiologyJohn J. Bergan and Luigi Pascarella5. Physiologic Testing in Venous DisordersJeffrey K. Raines and Jose I. Almeida6. Inappropriate Leukocyte Activation in Venous DiseasePhilip Coleridge Smith7. Molecular Basis of Venous Insufficiency8. Chronic Venous Insufficiency: Molecular Abnormalities and Ulcer FormationJoseph D. Raffetto9. Pathophysiology of Chronic Venous InsufficiencyPeter J. Pappas, Brajesh K. Lal, Frank T. Padberg Jr., Robert W. Zickler, and Walter N. Duran10. Mechanism and Effects of Compression TherapyHugo Partsch11. Classifying Venous DiseaseBo ElkofPart II: Primary Superficial Venous Insufficiency12. Risk Factors, Manifestations, and Clinic Examination of the Patient with Primary Venous InsufficiencyJohn J. Bergan13. Sclerosing AgentsA. Cavezzi and M. Izzo14. Sclerotherapy Treatment of TelangiectasiasRobert A. Weiss and Margaret A. Weiss15. Complications and Adverse Sequelae of SclerotherapyMitchel P. Goldman16. Laser Treatment of Telangiectasias and Reticular VeinsNeil Sadick and Lian Sorhaindo17. Overview: Treatment of Venous InsufficiencyJohn J. Bergan18. Ultrasound Examination of the Patient with Primary Venous InsufficiencyLuigi Pascarella and Lisa Mekenas19. Sclerotherapy and Ultrasound SclerotherapyPaul K. Thibault20. Sclerofoam for Treatment of Varicose VeinsJeanjerome Guex21. Sclerosants in Microfoam: A New Approach in AngiologyJuan Cabrera, Maria V. Rubia, and Juan Cabrera Jr.22. Ultrasound Guided Catheter and Foam Therapy for Venous InsufficiencyLuigi Pascarella and John J. Bergan23. Principles of Treatment of Varicose VeinsSteven E. Zimmet24. Inversion Stripping of the Saphenous VeinJohn J. Bergan25. Neovascularization: An Adverse Response to Proper Groin DissectionMarianne De Maeseneer26. The Changing Importance of the Saphenous Vein: Treating vs. Non-treatmentPaul Pittaluga, Chastanet S, Locret T27. Principles of Ambulatory PhlebectomyJose I. Almeida and Jeffrey K. Raines28. Powered Phlebectomy in Surgery of Varicose VeinsNick Morrison29. Endovenous Radiofrequency and Laser AblationNick Morrison30. Treatment of Small Saphenous Vein RefluxKenneth Myers, Amy Clough, Stefania Roberts, and Damien Jolley31. Recurrent Varicose Veins After Operative TreatmentMichel Perrin32. Use of System-Specific Questionnaires and Determination of Quality of Life After Treatment of Varicose VeinsA C Shepherd, M Davis, and A H Davies33. Pelvic Congestion Syndrome: Diagnosis and TreatmentG D RichardsonPart III: Venous Thromboembolism34. The Epidemiology of Venous Thromboembolism in the Community: Implications for Prevention and ManagementJohn A. Heit35. Fundamental Mechanisms in Venous Thrombosis: New InsightsJose A. Diaz, Daniel D. Myers Jr., and Thomas W. Wakefield36. Congenital and Acquired Hypercoagulable SyndromesJocelyn A. Segall and Timothy K. Liem37. New Ways To Prevent Venous Thromboembolism: Inhibition of Factor Xa and ThrombinDavid Bergqvist38. Diagnosis of Deep Venous ThrombosisDavid A. Frankel and Warner P. Bundens39. Thrombotic Risk Assessment: A Hybrid ApproachJoseph A. Caprini40. Venous Thromboembolism Prophylaxis in the General Surgical PatientJ.I. Arcelus and Joseph A. Caprini41. Conventional Treatment of Deep Venous ThrombosisGraham F. Pineo and Russell D. Hull42. The Diagnosis and Management of Heparin-Induced ThrombocytopeniaTheodore E. Warkentin43. Operative Venous ThrombectomyAnthony J. Comerota and Steven S. Gale44. Permanent Vena Cava Filters: Indications, Filter Types, and ResultsAli F. AbuRahma and Patrick A. Stone45. Complications of Vena Cava FiltersTeresa L. Carman and Linda M. Graham46. Temporary Filters and Prophylactic IndicationsJohn C. McCallum and Nikhil Kansal47. Thrombolytic Therapy for Acute Venous ThrombosisAnthony J. Comerota and Santiago Chahwan48. Percutaneous Mechanical Thrombectomy in the Treatment of DVTColleen M. Johnson, Pritham P. Reddy, and Robert B. McLafferty49. Diagnosis and Management of Primary Axillo-Subclavian Venous ThrombosisNiren Angle50. Subclavian Vein Obstruction: Techniques for Repair and BypassRichard J. Sanders51. Superficial Thrombophlebitis: Recommendations for Diagnosis and ManagementJoann M. LohrPart IV: Chronic Venous Insufficiency52. The Primary Cause of Chronic Venous InsufficiencyMichel Perrin, Oscar Maleti, and Marzia Lugli53. Conventional Surgery for Chronic Venous InsufficiencyWilliam Marston54. Subfascial Endoscopic Perforating Vein Surgery (SEPS) for Chronic Venous InsufficiencyPeter Gloviczki, Manju Karla, and Alessandra Puggioni55. Ultrasound Guided Sclerotherapy of Perforating Veins In Chronic InsufficiencyFedor Lurie, Alessandra Puggionu, and Robert L. Kistner56. Perforating VeinsJohn J. Bergan and Luigi Pascarella57. Endovenous Treatment of Iliocaval OcclusionPatricia E. Thorpe and Francisco J. Osse58. Popliteal Venous EntrapmentSeshadri Raju59. Valvuloplasy In Primary Venous Insufficiency: Development, Performance, and Long-Term ResultsRobert L. Kistner, Elna Masuda, and Fedor Lurie60. Prosthetic Venous ValvesMichael C. Dalsing61. Post-Thrombotic Syndrome: Clinical Features, Pathology, and TreatmentSeshadri Raju62. Efficacy of Veno-Active Drugs In Chronic Venous Disease: Survey Of Evidence, Synthesis, And Tentative RecommendationsMichel Perrin and A.A. Ramelet63. Medical Management of the Venous Leg Ulcer: Wound Dressings and Adjuvant AgentsPart V: Congenital Venous Abnormalities64. Venous Malformations and Tumors: Etiology, Diagnosis, and ManagementBB Lee and J Laredo
John J. Bergan, MD, FACS, FACPh, FRCS, pioneered a new era of diagnosis and treatment for venous conditions, expanding the scope of research and discovering new frontiers in phlebology. As a clinical vascular surgeon, physician, scientist, and respected teacher of vascular surgery, he has published over 800 academic papers and authored or edited more than 40 textbooks. He has served as president for all the major vascular surgery societies and resided on editorial boards of all major surgical and vascular journals, including the Journal of Vascular Surgery, Annals of Vascular Surgery, and the British Journal of Surgery. Additionally, he was a co-founder of the American Venous Forum and American College of Phlebology. Nisha Bunke, MD, FACPh, is the Director of La Jolla Vein Care, Volunteer Clinical Instructor of Surgery at the University of California San Diego School of Medicine, member of the Scripps Ximed Medical Group.
This continues to be the go-to book for venous disease. This second
edition is complete with up-to-date, evidence-based information on
medical therapy, minimally invasive and surgical procedures, and
other aspects of treatment. The tables, diagrams, illustrations,
and photographs make for a very helpful addendum to the detailed
but easy-to-read text. This is a must-read for vascular trainees
who might not get much exposure to venous disease in their training
programs. And it should be included in libraries of anyone taking
care of patients with venous disease.
*Doody's Notes*
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